ALTTO
Description:
ALTTO-Adjuvant Lapatinib and/or Trastuzumab Treatment Optimisation study: A randomised, multi-centre, open-label, phase III study of adjuvant trastuzumab, their sequence and their combination in patients with HER2/ErbB2 positive primary breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Steve Kelly | Plymouth Hospitals NHS Trust | Open |
| Dr A Goodman | Royal Devon & Exeter NHS Foundation Trust | Open |
BBC Study
Description:
BBC Study A national population-based study of treatment effect and endocrine, genetic and cellular risk factors for contralateral primary breast cancer in women in Britain.
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Mark Napier | Northern Devon Healthcare NHS Trust | Open |
| Mr. Roger Watkins | Plymouth Hospitals NHS Trust | Open |
| Mr. Peter Cox | Royal Cornwall Hospitals NHS Trust | Open |
| Dr Anne Hong | Royal Devon & Exeter NHS Foundation Trust | Open |
| No. Principal Investigator | South Devon Healthcare NHS Trust | Not Done |
BBC-NCRN cohort
Description:
BBC-NCRN cohort British Breast Cancer Study - NCRN cohort
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Mark Napier | Northern Devon Healthcare NHS Trust | Open |
| Mr. Roger Watkins | Plymouth Hospitals NHS Trust | Open |
| No. Principal Investigator | Royal Cornwall Hospitals NHS Trust | In Set Up |
| Dr. Anne Hong | Royal Devon & Exeter NHS Foundation Trust | Open |
| Mr. Peter Donnelly | South Devon Healthcare NHS Trust | Open |
BISMARK
Description:
BISMARK- An open label RCT comparing a marker directed schedule of Zoledronic acid with a fixed schedule of Zoledronic acid administration in advanced breast ca. with metastatic bone disease.
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Duncan Wheatley | Royal Cornwall Hospitals NHS Trust | Open |
BRCA Trial
Description:
BRCA Trial Breakthrough Breast Cancer & Cancer Research UK Genetic Breast Cancer Trial: A randomised phase II pilot trial of docetaxel compared to carboplatin for patients with metastatic genetic breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Anne Hong | Royal Devon & Exeter NHS Foundation Trust | Open |
| Dr Peter Bliss | South Devon Healthcare NHS Trust | Open |
BRCA3
Description:
Identification and Molecular Analyses of Families with Susceptibility to Breast Cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Carole Brewer | Northern Devon Healthcare NHS Trust | Open |
| Dr. Carole Brewer | Plymouth Hospitals NHS Trust | Open |
| Dr. Carole Brewer | Royal Cornwall Hospitals NHS Trust | Open |
| Dr. Carole Brewer | Royal Devon & Exeter NHS Foundation Trust | Open |
| Dr. Carole Brewer | South Devon Healthcare NHS Trust | Open |
EMBRACE
Description:
EMBRACE Epidemiological study of BRCA1 and BRCA2 mutation carriers
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Carole Brewer | Northern Devon Healthcare NHS Trust | Open |
| Dr. Carole Brewer | Plymouth Hospitals NHS Trust | Open |
| Dr. Carole Brewer | Royal Cornwall Hospitals NHS Trust | Open |
| Dr. Carole Brewer | Royal Devon & Exeter NHS Foundation Trust | Open |
| Dr. Carole Brewer | South Devon Healthcare NHS Trust | Open |
FBCS
Description:
FBCS-Identification and molecular analyses of families with susceptibility to breast cancer
Phase: Open
Type: NCRN|
No current active trials.
|
|---|
GLACIER
Description:
GLACIER-A study to investigate the Genetics of LobulAr Carcinoma In situ in EuRope
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr David Hwang | Northern Devon Healthcare NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
IBIS-II DCIS
Description:
IBIS-II An international multicentre study of Anastrozole vs Placebo in Postmenopausal Women at Increased Risk of Breast Cancer. and also An international multicentre study of Anastrozole vs Tamoxifen in Postmenopausal Women with Ductal carcinoma in Situ
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Mr. Roger Watkins | Plymouth Hospitals NHS Trust | Open |
| Dr. Donna Christensen | Royal Cornwall Hospitals NHS Trust | Open |
| Dr D Ferguson | Royal Devon & Exeter NHS Foundation Trust | Open |
IBIS-II Prevention
Description:
IBIS-II Prevention -IBIS-II Prevention: An international multicentre study of Anastrozole vs Placebo in Postmenopausal Women at Increased Risk of Breast Cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Mr Roger Watkins | Plymouth Hospitals NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
ICICLE
Description:
ICICLE -A study to Investigate the genetiCs of In situ Carcinoma of the ductaL subtypE
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr David Hwang | Northern Devon Healthcare NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
IMPORT LOW
Description:
IMPORT LOW-Randomised trial testing intensity modulated and partial organ radiotherapy following breast conservation surgery for early breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Duncan Wheatley | Royal Cornwall Hospitals NHS Trust | Open |
| Dr Andrew Goodman | South Devon Healthcare NHS Trust | Open |
NCRN010 (AVEREL)
Description:
NCRN010 (AVEREL)
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Anne Hong | Royal Devon & Exeter NHS Foundation Trust | Open |
NCRN024 - INDUSTRY STUDY
Description:
A phase III randomized, double blind, placebo controlled clinical trial to evaluate the efficacy and safety of Pertuzumab + Trastuzumab + Docetaxel vs. placebo + Trastuzumab + Docetaxel in previously untreated HER-2 positive metastatic breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | Open |
Neo-Excel
Description:
Neo-Excel Neoadjuvant trial of pre-operative exemestane or letrozole +/-celecoxib in the treatment of ER-positive postmenopausal early breast breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Mr Mike Hannemann | Northern Devon Healthcare NHS Trust | Open-On hold to recruitment |
| Mr. Roger Watkins | Plymouth Hospitals NHS Trust | In Set Up |
OPTION
Description:
OPTION Ovarian Protection Trial -Randomised trial to assess the value of Goserelin ovarian suppression in the prevention of chemotherapy-associated menopause in premenopausal women with early breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Duncan Wheatley | Royal Cornwall Hospitals NHS Trust | Open |
PARP BRCA trial
Description:
PARP BRCA trial-A Cancer Research UK Phase II Proof of Principle Trial of the activity of the intravenous PARP-1 inhibitor, AG-014699, in known carriers of a BRCA 1 or BRCA 2 mutation with locally advanced or metastatic breast or advanced ovarian cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Martin Highley | Plymouth Hospitals NHS Trust | Open |
Persephone
Description:
Persephone:Phase III RCT of 6 vs 12 months treatment of trastuzumab in patients with HER-2 positive early breast cancer
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr David Hwang | Northern Devon Healthcare NHS Trust | Open |
| Dr Andrew Goodman | South Devon Healthcare NHS Trust | Open |
POETIC
Description:
POETIC-Trial of Perioperative Endocrine Therapy - Individualising Care
Phase: In Setup
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr David Hwang | Northern Devon Healthcare NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | In Set Up |
PRIME II
Description:
PRIME II Post-operative Radiotherapy In Minimum-risk Elderly Phase II
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr David Hwang | Northern Devon Healthcare NHS Trust | Open |
| Dr. Chris Tyrrell | Plymouth Hospitals NHS Trust | Open |
| Dr. Andrew Goodman | Royal Devon & Exeter NHS Foundation Trust | Open |
| Dr. Peter Bliss | South Devon Healthcare NHS Trust | Open |
SEARCH
Description:
SEARCH - A population based study of genetic predispositions and gene-environment interactions in breast cancer in East Anglia - A population based study of genetic predisposition and gene-environment interactions in colorectal cancer - A population based
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | Open |
SoFEA
Description:
SoFEA -A partially-Blind phase III randomised trial of Fulvestrant (Faslodex TM) with or without concomitant Anastrozole (ArimidexTM)compared with exemestane in post-menopausal women with ER+velocally advanced /metastatic breast cancer following progressi
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Mark Napier | Northern Devon Healthcare NHS Trust | Open |
| Dr. Duncan Wheatley | Royal Cornwall Hospitals NHS Trust | Open |
SUPREMO
Description:
SUPREMO Selective use of postmastectomy radiotherapy after mastectomy
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Mark Napier | Northern Devon Healthcare NHS Trust | In Set Up |
| Royal Devon & Exeter NHS Foundation Trust | In Set Up |
| Dr Peter Bliss | South Devon Healthcare NHS Trust | Open |
TACT Trial Long Term QL (sub-study)
Description:
TACT Trial Long Term QL (sub-study)
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Plymouth Hospitals NHS Trust | Open |
| South Devon Healthcare NHS Trust | Open |
TNT Trial
Description:
TNT Trial-Triple Negative Breast Cancer Trial: A randomised phase III trial of carboplatin compared to docetaxel for patients with metastatic or recurrent locally advanced ER-, PR- and HER2- breast cancer.
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr David Hwang | Northern Devon Healthcare NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | In Set Up |
| Dr Peter Bliss | South Devon Healthcare NHS Trust | Open |
ZICE
Description:
ZICE A randomised phase III, open-label, multicentre, parallel group clinical trial to evaluate and compare the efficacy, safety profile and tolerability of oral ibandronate versus intravenous zoledronate in the treatment of breast cancer patients with bo
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | Open |