ADMIRE
Description:
ADMIRE-Does the addition of mitoxantrone improve response? A randomised phase II trial of fludarabine, cyclophosphamide and rituximab mitoxantrone in previously untreated CLL.
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
| South Devon Healthcare NHS Trust | Open |
AML 16
Description:
AML 16 National Cancer Research Institute Acute Myeloid Leukaemia and High Risk Myelodysplastic Syndrome Trial 16
Phase: In Setup, Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| No. Principal Investigator | Northern Devon Healthcare NHS Trust | Open |
| Dr. Hannah Hunter | Plymouth Hospitals NHS Trust | Open |
| Dr. Anton Kruger | Royal Cornwall Hospitals NHS Trust | Open |
| Dr. Miles Joyner | Royal Devon & Exeter NHS Foundation Trust | Open |
| Dr. Deborah Turner | South Devon Healthcare NHS Trust | Open |
AML 17
Description:
AML 17-Working parties on leukaemia in adults and children trial in acute myeloid leukaemia or high risk myelodysplastic syndrome 17
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Claudius Rudin | Northern Devon Healthcare NHS Trust | Open |
| Dr Hannah Hunter | Plymouth Hospitals NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
| South Devon Healthcare NHS Trust | Open |
FCLL
Description:
FCLL-A Genetic Study of Chronic Lymphocytic Leukaemia and Other Lymphoproliferative Disease
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Northern Devon Healthcare NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
MDSBio1
Description:
MDSBio1:Molecular and functional characterisation of bone marrow function in normal subjects, myelodysplastic syndromes (MDS) and secondary disorders of haematopoiesis
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr Hannah Hunter | Plymouth Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
MRC PT1
Description:
MRC PT1 A Medical Research Council Randomised Trial to Compare Aspirin versus Hydroxyurea/Aspirin in Intermediate Risk Primary Thrombocythaemia and Hydroxyurea/Aspirin versus Anagrelide/Aspirin in High Risk Primary Thrombocythaemia
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Anton Kruger | Royal Cornwall Hospitals NHS Trust | Open |
| Dr. Miles Joyner | Royal Devon & Exeter NHS Foundation Trust | Open |
| Dr. Deborah Turner | South Devon Healthcare NHS Trust | Open |
MRC UKALL XII
Description:
MRC UKALL XII Medical Research Council Trial for Adult Patients with Acute Lymphoblastic Leukaemia Under 56 years of Age. To compare related donor transplant versus autologous transplant versus chemotherapy.
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Dr. Simon Rule | Plymouth Hospitals NHS Trust | Closed |
| Dr. Anton Kruger | Royal Cornwall Hospitals NHS Trust | Closed |
| Dr. Miles Joyner | Royal Devon & Exeter NHS Foundation Trust | Closed |
| Dr. Deborah Turner | South Devon Healthcare NHS Trust | Closed |
MRD feasibility study
Description:
MRD feasibility study-Minimal Residual Disease Monitoring In Adult Acute Lymphoblastic Leukaemia: A Laboratory Feasibility Study
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Devon & Exeter NHS Foundation Trust | Open |
Myeloma X Relapse (Intensive)
Description:
Relapsed Myeloma:Myeloma X Relapse Intensive
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Plymouth Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
| South Devon Healthcare NHS Trust | Open |
MYELOMA XI
Description:
Randomised comparisons in myeloma patients of all ages of thalidomide, lenalidomide and bortezomib combinations and maintenance lenalidomide
Phase: In Setup
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | In Set Up |
| Royal Devon & Exeter NHS Foundation Trust | In Set Up |
NCRN042
Description:
OMB110913: A Phase III, Open Label, Randomized trial of Ofatumumab in combination with Fludarabine-Cyclophosphamide vs. Fludarabine-Cyclophosphamide Combination in Subjects with Relapsed Chronic Lymphocytic Leukemia
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | Open |
NCRN043
Description:
NCRN043-A phase III, open label, randomized, multicenter trial of Ofatumumab-Chlorambucil combination vs. Chlorambucil Monotherapy in previously untreated patients with B-Cell Chronic Lymphocytic Leukemia
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Plymouth Hospitals NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
NCRN043
Description:
NCRN043-A phase III, open label, randomized, multicenter trial of Ofatumumab-Chlorambucil combination vs. Chlorambucil Monotherapy in previously untreated patients with B-Cell Chronic Lymphocytic Leukemia
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Plymouth Hospitals NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
REGiM
Description:
A randomised controlled trial of prolonged treatment with darbepoetin alpha (EPO), with or without recombinant human granulocyte colony stimulating factor (G-CSF), versus best supportive care in patients with low-risk myelodysplastic syndromes (MDS)
Phase: In Setup
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | In Set Up |
| Royal Devon & Exeter NHS Foundation Trust | In Set Up |
| South Devon Healthcare NHS Trust | In Set Up |
SPIRIT 2
Description:
Prospective International RandomIsed Trial 2: A phase III, prospective randomised comparison of imatinib (STI571, Glivec/Gleevec) 400mg daily versus dasatinib (Sprycel) 100mg daily in patients with newly-diagnosed chronic phase chronic myeloid leukaemia.
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Royal Cornwall Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |
| South Devon Healthcare NHS Trust | Open |
TOPPS
Description:
TOPPS-A Randomised Controlled Trial of Prophylactic Vs No-Prophylactic Platelet Transfusions in Patients with Haematological Malignancies (TOPPS: Trial Of Prophylactic PlateletS)
Phase: Open
Type: NCRN|
Contact Person
|
Location
|
Stage
|
|---|
| Plymouth Hospitals NHS Trust | Open |
| Royal Devon & Exeter NHS Foundation Trust | Open |